The genetics of obesity: from discovery to biology

2021/09/23 by Ruth J. F. Loos, Giles S.H. Yeo, Giles S. H. Yeo · 14 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Diet and metabolism studies #Genetic Associations and Epidemiology #Regulation of Appetite and Obesity

paper · pdf · doi:10.1038/s41576-021-00414-z

crossref issued 2021/09/23 · crossref published 2021/09/23 · crossref published-online 2021/09/23 · openalex publication_date 2021/09/23 · crossref created 2021/09/23 · crossref published-print 2022/02/01 · crossref deposited 2024/12/11 · openalex created_date 2025/10/10 · crossref indexed 2026/07/28 · openalex updated_date 2026/07/31

Cited by

• Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
• Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
• Definition and diagnostic criteria of clinical obesity
• The transition from preclinical to clinical obesity: the importance of a borderline stage
• Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans
• Associations of Phthalate Exposure With Adiposity and Metabolic Syndrome in US Adolescents and Adults, NHANES 2013 to 2018
• Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS
• JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism
• Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease
• Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation
• Multimodal (Bio)Markers and Risk of Obesity – A Comprehensive Scoping Review
• 3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesity
• 2026 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
• Drosophila as a Genetic Model System to Study Organismal Energy Metabolism