2020/11/18 by Hossam Kadry, Behnam Noorani, Luca Cucullo · 14 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Barrier Structure and Function Studies #Drug Transport and Resistance Mechanisms #Ion Transport and Channel Regulation
paper · pdf · doi:10.1186/s12987-020-00230-3
openalex publication_date 2020/11/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02
The blood-brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain-blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Finally, we discussed several biomarkers that can help to assess the BBB permeability and integrity in-vitro or in-vivo and briefly explain their advantages and disadvantages.