2003/07/02 by Jörg Uhde, Joerg Uhde, Manfred Keller +5
Biochemistry, Genetics and Molecular Biology · Medicine · Physics and Astronomy · Social Sciences · #Cardiomyopathy and Myosin Studies #Cellular Mechanics and Interactions #Digitalization, Law, and Regulation #Force Microscopy Techniques and Applications #Law and Political Science #Medical and Health Sciences Research #cond-mat.soft #physics.bio-ph #q-bio
paper · pdf · doi:10.1103/physrevlett.93.268101
published as Phys. Rev. Lett. 93, 268101 (2004) · 4 pages, 3 figures
arxiv created 2003/07/02 · openalex publication_date 2008/01/01 · arxiv updated 2009/11/30 · openalex created_date 2016/06/24 · openalex updated_date 2026/04/28
We present a study on filamentous actin solutions containing heavy meromyosin subfragments of myosin II motor molecules. We focus on the viscoelastic phase behavior and internal dynamics of such networks during adenosine-triphosphate depletion. By combining microrheology and fluorescence microscopy, we observed a sol-gel transition accompanied by a sudden onset of directed filament motion. We interpret the sol-gel transition in terms of myosin II enzymology, and suggest a "zipping" mechanism to explain the filament motion in the vicinity of the sol-gel transition.