Mechanisms of SARS-CoV-2 entry into cells

2021/10/05 by Cody B. Jackson, Michael Farzan, Bing Chen +1 · 31 citations
Agricultural and Biological Sciences · Medicine · #Animal Virus Infections Studies #COVID-19 Clinical Research Studies #SARS-CoV-2 and COVID-19 Research

paper · pdf · doi:10.1038/s41580-021-00418-x

crossref issued 2021/10/05 · crossref published 2021/10/05 · crossref published-online 2021/10/05 · openalex publication_date 2021/10/05 · crossref created 2021/10/05 · crossref deposited 2021/12/20 · crossref published-print 2022/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/30

Citations

• Coronavirus envelope protein: current knowledge
• A pneumonia outbreak associated with a new coronavirus of probable bat origin
• Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
• Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
• Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
• The proximal origin of SARS-CoV-2
• Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
• Structural basis of receptor recognition by SARS-CoV-2
• Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
• Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
• Cell entry mechanisms of SARS-CoV-2
• Remdesivir for the Treatment of Covid-19 — Final Report
• SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
• Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
• Factors associated with COVID-19-related death using OpenSAFELY
• Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
• Neuropilin-1 is a host factor for SARS-CoV-2 infection
• CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
• Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
• Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
• Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Cited by

• TMPRSS2-induced Golgi disruption restricts the incorporation of virus envelope glycoproteins into virions
• SARS-CoV-2: The Interplay Between Evolution and Host Immunity
• COVID-19 disease and autoimmune disorders: A mutual pathway
• Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection
• RECUR: identifying recurrent amino acid substitutions from multiple sequence alignments
• Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation
• Structural Immunology of SARS‐CoV‐2
• Localizing the Glycan Binding Sites of SARS-CoV-2 Receptor-Binding Domain
• Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
• Adhesion-driven vesicle translocation through membrane-covered pores
• ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023
• Neutralizing nanobodies against SARS-CoV-2 recognizing highly conserved epitopes at the Spike’s S2 subunit
• Does COVID‐19 cause or worsen LUT dysfunction, what are the mechanisms and possible treatments? ICI‐RS 2023
• The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications
• Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study
• Long-term effects of SARS-CoV-2 infection on human brain and memory
• SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release
• Organoids in respiratory virus research: advances and perspectives
• SARS‐CoV‐2 Spike Protein as a Target of the COVID‐19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes
• Next-Generation Vaccines against COVID-19 Variants: Beyond the Spike Protein
• Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis
• SARS-CoV-2 infection enhancement by amphotericin B: implications for disease management
• Systemic profiling of immune responses in healthy adults vaccinated with an RBD-targeting COVID-19 mRNA vaccine
• Binding ability of Delta and Omicron towards the angiotensin-converting enzyme 2 receptor and antibodies: a computational study
• Coronaviruses: Pandemic SARS-CoV-2
• Stringent selection drives convergence toward omicron-like SARS-CoV-2 receptor-binding motifs
• Therapeutic BCG vaccine protects against long COVID: The BATTLE randomized clinical trial
• Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence
• An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
• Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant
• Functional and structural characterization of the SARS-CoV-2 spike N481K mutation
• Ethanol exposure suppresses Microglia pro-inflammatory response induced by SARS-CoV2-Spike protein