2020/01/31 by Yushun Wan, Jian Shang, Rachel L. Graham +2 · 31 citations
Medicine · #COVID-19 Clinical Research Studies #SARS-CoV-2 and COVID-19 Research #SARS-CoV-2 detection and testing
paper · doi:10.1128/jvi.00127-20
openalex publication_date 2020/01/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. One of the goals of SARS-CoV research was to build an atomic-level iterative framework of virus-receptor interactions to facilitate epidemic surveillance, predict species-specific receptor usage, and identify potential animal hosts and animal models of viruses. Based on the sequence of 2019-nCoV spike protein, we apply this predictive framework to provide novel insights into the receptor usage and likely host range of 2019-nCoV. This study provides a robust test of this reiterative framework, providing the basic, translational, and public health research communities with predictive insights that may help study and battle this novel 2019-nCoV.