Maternal Immunological Adaptation During Normal Pregnancy

2020/10/07 by Bahaa Abu-Raya, Christina Michalski, Manish Sadarangani +1 · 3 citations
Immunology and Microbiology · Medicine · #Reproductive System and Pregnancy #COVID-19 Impact on Reproduction #Pregnancy and Medication Impact

paper · pdf · doi:10.3389/fimmu.2020.575197

openalex publication_date 2020/10/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.

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