The spectrum of inflammatory responses

2021/11/25 by Ruslan Medzhitov · 1 voice · 9 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Adipokines, Inflammation, and Metabolic Diseases #Immune Response and Inflammation #Inflammasome and immune disorders

paper · doi:10.1126/science.abi5200

openalex publication_date 2021/11/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense of homeostasis and the functional and structural integrity of tissues and organs. Recent advances have uncovered a broad range of biological processes that involve inflammatory control, calling for a renewed framework of inflammation beyond its classical roles in defense from infection and injury. In this Review, new perspectives on inflammation biology are discussed and new research directions are suggested to address the fundamental gaps in our current understanding.

Citations

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Discussions

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