Hallmarks of T cell aging

2021/05/13 by Marı́a Mittelbrunn, Maria Mittelbrunn, Guido Kroemer · 14 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immune Cell Function and Interaction #Single-cell and spatial transcriptomics #T-cell and B-cell Immunology

paper · doi:10.1038/s41590-021-00927-z

crossref issued 2021/05/13 · crossref published 2021/05/13 · crossref published-online 2021/05/13 · openalex publication_date 2021/05/13 · crossref created 2021/05/13 · crossref published-print 2021/06/01 · crossref deposited 2023/11/03 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/30

Citations

• Chronic inflammation in the etiology of disease across the life span
• Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
• Glycolysis – a key player in the inflammatory response
• Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
• A fresh look at the T helper subset dogma

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• Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging
• The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination
• Immune responses in aging adults
• Aging disrupts sympathetic innervation of the thymus
• Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
• Reprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging
• Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
• Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV
• Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation
• The multiomics blueprint of the individual with the most extreme lifespan