Atherosclerosis: Recent developments

2022/05/01 by Johan Björkegren, Aldons J. Lusis · 11 citations
Immunology and Microbiology · Medicine · #Atherosclerosis and Cardiovascular Diseases #Adipokines, Inflammation, and Metabolic Diseases #Immune cells in cancer

paper · pdf · doi:10.1016/j.cell.2022.04.004

openalex publication_date 2022/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.

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