2020/01/01 by Takuya Ishii, Kazunori Nagao, Hirohisa Ohmiya · 1 citation
Chemistry · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
paper · pdf · doi:10.1039/d0sc01538e
openalex publication_date 2020/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called "Breslow intermediate," is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-heterocyclic carbene (NHC)-catalyzed radical reactions have been developed. This minireview highlights the recent progress and developments in NHC-based radical catalysis. This minireview is categorized according to the reaction types; oxidation type reaction and carbon-carbon bond formation through single electron transfer/radical-radical coupling.