2021/08/05 by Wenlong Li, Eng San Thian, Miao Wang +2 · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · #Antimicrobial agents and applications #Bacterial biofilms and quorum sensing #Nanoplatforms for cancer theranostics
paper · pdf · doi:10.1002/advs.202100368
openalex publication_date 2021/08/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Healthcare-acquired infections as well as increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene have attracted great interest, in particular, the emergence of surface design strategies offer an effective alternative to antibiotics, thereby preventing the possible development of bacterial resistance. In this review, recent progress on advanced surface modifications to prevent bacterial infections are addressed comprehensively, starting with the key factors against bacterial adhesion, followed by varying strategies that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense and targeted bactericidal system, are proposed with increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies to resist healthcare-associated infections are discussed, with promising prospects of developing novel antimicrobial materials.