2020/01/01 by Zhen Yang, Mateus L. Stivanin, Igor D. Jurberg +1 · 3 citations
Chemistry · #Catalytic C–H Functionalization Methods #Cyclopropane Reaction Mechanisms #Synthesis and Catalytic Reactions
paper · doi:10.1039/d0cs00224k
openalex publication_date 2020/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Carbenes are important intermediates in organic chemistry and have been widely applied in various types of organic reactions, ranging from cycloaddition reactions and sigmatropic rearrangements to C-H functionalizations, thus allowing the rapid construction of densely functionalized molecules. Over the past decades, remarkable progress has been achieved in metal-catalyzed carbene transfer reactions. Nevertheless, realizing these transformations under milder and/or greener conditions is still highly desirable. Only recently, visible light-promoted carbene transfer reactions of diazo compounds via free carbene intermediates have emerged as a practical, mild and powerful tool. In this tutorial review, we summarize the latest advances in the area, aiming at providing a clear overview on reaction design, mechanistic scenarios and potential future developments.