Recent developments in nickel-catalyzed intermolecular dicarbofunctionalization of alkenes

2020/01/01 by Joseph Derosa, Omar Apolinar, Taeho Kang +2 · 494 citations
Chemistry · #Catalysis #Catalytic Alkyne Reactions #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Chemistry #Combinatorial chemistry #Computational chemistry #Intermolecular force #Molecule #Nickel #Organic chemistry

paper · pdf · doi:10.1039/c9sc06006e

published in Chemical Science 11(17), 4287-4296 (Royal Society of Chemistry)

openalex publication_date 2020/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Nickel-catalyzed three-component alkene difunctionalization has rapidly emerged as a powerful tool for forging multiple C–C bonds in a single step.

Citations

• Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
• Mechanisms of Nickel-Catalyzed Cross-Coupling Reactions

Cited by

• Dinuclear Ni enabled reductive diarylation of dienes: Intramolecular comproportionation as the key mechanistic driver
• Reactivity Studies of Bipyridine-Ligated Nickel(I) and Nickel(0) Complexes Inform the Mechanism in Modern Cross-Coupling Reactions
• Manganese‐Catalyzed Anti‐Markovnikov Hydroarylation of Enamides: Modular Synthesis of Arylethylamines
• Pseudo-4-component photoredox-catalyzed alkylative amidination/carbamoylation of styrenes with isocyanides and redox-active esters
• Nickel-Catalyzed Dicarbofunctionalization of Alkenes

Related

• Nickel-Catalyzed Dicarbofunctionalization of Alkenes
• Mechanisms of Nickel-Catalyzed Coupling Reactions and Applications in Alkene Functionalization
• Three-component, stereoselective C–N bond forming alkene difunctionalization
• Ligand -controlled nickel-catalyzed C–O bond cleavage of silyl enol ether for the divergent synthesis of aryl alkenes and silicon-containing product
• Nickel-catalyzed dynamic kinetic cross-electrophile coupling of benzylic alcohols and alkenyl triflates