Recepción del testimonio

1994/01/01 by Nayoung Kim, Hong Kwan Kim, Kyungjong Lee +19 · 16 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Psychology · Social Sciences · #Cancer Genomics and Diagnostics #Immune cells in cancer #Legal processes and jurisprudence #Memory, violence, and history #Single-cell and spatial transcriptomics

paper · pdf · doi:10.1038/s41467-020-16164-1

openalex publication_date 1994/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/24

Abstract

Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent histological lung cancer type diagnosed at stage IV in over 40% of all cases. From 208,506 cells populating the normal tissues or early to metastatic stage cancer in 44 patients, we identify a cancer cell subtype deviating from the normal differentiation trajectory and dominating the metastatic stage. In all stages, the stromal and immune cell dynamics reveal ontological and functional changes that create a pro-tumoral and immunosuppressive microenvironment. Normal resident myeloid cell populations are gradually replaced with monocyte-derived macrophages and dendritic cells, along with T-cell exhaustion. This extensive single-cell analysis enhances our understanding of molecular and cellular dynamics in metastatic lung cancer and reveals potential diagnostic and therapeutic targets in cancer-microenvironment interactions.

Citations

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