2021/01/19 by Catherine Bridges, Amanda C. Daulagala, Antonis Kourtidis · 6 citations
Biochemistry, Genetics and Molecular Biology · #Cancer-related molecular mechanisms research #RNA Research and Splicing #RNA modifications and cancer
paper · pdf · doi:10.1083/jcb.202009045
openalex publication_date 2021/01/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Subcellular localization of RNAs has gained attention in recent years as a prevalent phenomenon that influences numerous cellular processes. This is also evident for the large and relatively novel class of long noncoding RNAs (lncRNAs). Because lncRNAs are defined as RNA transcripts >200 nucleotides that do not encode protein, they are themselves the functional units, making their subcellular localization critical to their function. The discovery of tens of thousands of lncRNAs and the cumulative evidence involving them in almost every cellular activity render assessment of their subcellular localization essential to fully understanding their biology. In this review, we summarize current knowledge of lncRNA subcellular localization, factors controlling their localization, emerging themes, including the role of lncRNA isoforms and the involvement of lncRNAs in phase separation bodies, and the implications of lncRNA localization on their function and on cellular behavior. We also discuss gaps in the current knowledge as well as opportunities that these provide for novel avenues of investigation.