2020/06/23 by Shenqiang Wang, Hua Zheng, Li Zhou +5
Chemistry · Materials Science · Medicine · #Antimicrobial agents and applications #Electrospun Nanofibers in Biomedical Applications #Wound Healing and Treatments
paper · doi:10.1021/acs.nanolett.0c01371
openalex publication_date 2020/06/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed to simultaneously overcome these hurdles. The FEMI hydrogel was fabricated through a Schiff-based reaction between ε-polylysine (EPL)-coated MnO 2 nanosheets (EM) and insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through a synergistic combination of EPL and “nanoknife-like” MnO 2 nanosheets, the FEMI hydrogel exhibited extraordinary antimicrobial capacities against MDR bacteria. The MnO 2 nanoenzyme reshaped the hostile oxidative wound microenvironment by decomposing the endogenous H 2 O 2 into O 2 . Meanwhile, the pH/redox dual-responsive FEMI hydrogel achieved a sustained and spatiotemporal controlled release of insulin to regulate the blood glucose. Our FEMI hydrogel demonstrated an accelerated MDR bacteria-infected diabetic wound healing in vivo and represents a versatile strategy for healing a broad range of tissue damages caused by diabetes.