2020/04/20 by Nagaraju Kerru, Lalitha Gummidi, Suresh Maddila +2 · 6 citations
Chemistry · #Synthesis and Biological Evaluation #Synthesis and Catalytic Reactions #Synthesis and biological activity
paper · pdf · doi:10.3390/molecules25081909
openalex publication_date 2020/04/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.