Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

2020/11/30 by Ali Punjani, Haowei Zhang, David J. Fleet · 29 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · Physics and Astronomy · #Advanced Electron Microscopy Techniques and Applications #Advanced X-ray Imaging Techniques #Electron and X-Ray Spectroscopy Techniques

paper · doi:10.1038/s41592-020-00990-8

crossref issued 2020/11/30 · crossref published 2020/11/30 · crossref published-online 2020/11/30 · openalex publication_date 2020/11/30 · crossref created 2020/11/30 · crossref published-print 2020/12/01 · crossref deposited 2024/12/11 · openalex created_date 2025/10/10 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/29

Citations

• Generalized Cross-Validation as a Method for Choosing a Good Ridge Parameter
• One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions
• MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps
• Noise2Noise: Learning Image Restoration without Clean Data
• Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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