Tutorial: a guide to performing polygenic risk score analyses

2020/07/24 by Shing Wan Choi, Timothy Shin Heng Mak, Timothy Shin-Heng Mak +1 · 21 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Genetic Associations and Epidemiology #Liver Disease Diagnosis and Treatment #Statistical Methods in Clinical Trials

paper · doi:10.1038/s41596-020-0353-1

crossref issued 2020/07/24 · crossref published 2020/07/24 · crossref published-online 2020/07/24 · openalex publication_date 2020/07/24 · crossref created 2020/07/24 · openalex created_date 2020/07/29 · crossref published-print 2020/09/01 · crossref deposited 2024/08/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/08/01

Citations

• Estimating Missing Heritability for Disease from Genome-wide Association Studies
• GCTA: A Tool for Genome-wide Complex Trait Analysis
• Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies
• PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
• Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
• The personal and clinical utility of polygenic risk scores

Cited by

• Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations
• Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures
• New Data Sources for Demographic Research
• Canine genome-wide association study identifies <i>DENND1B</i> as an obesity gene in dogs and humans
• Role of genetics in the age-related testosterone decline in men: a UK Biobank study
• Applying Genetic Risk Score to Improve Risk Assessment of New‐Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large‐Scale Prospective Cohort Study
• Simulated climate change magnifies genetic vulnerabilities from mutation load and maladaptation
• Heterogeneous associations of polygenic indices of 35 traits with mortality: a register-linked population-based follow-up study
• Effects of parental socioeconomic status on offspring’s fetal neurodevelopment
• Biobanking with genetics shapes precision medicine and global health
• TGF-β Pathway–Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method
• Genetic susceptibility for neurodevelopmental disorders in children born to women with epilepsy
• Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
• Grapevine pangenome facilitates trait genetics and genomic breeding
• Learning Explainable Imaging-Genetics Associations Related to a Neurological Disorder
• Genome-wide association studies
• Methodologies underpinning polygenic risk scores estimation: a comprehensive overview
• Multiomics Analyses Reveal Microbiome–Gut–Brain Crosstalk Centered on Aberrant Gamma-Aminobutyric Acid and Tryptophan Metabolism in Drug-Naïve Patients with First-Episode Schizophrenia
• Polygenic risk scores of chronic obstructive pulmonary disease (COPD) predict lung function decline and early COPD: results from COSYCONET
• High rates of Parkinson’s disease diagnosis in the autistic population: True co-occurrence or a product of overlapping traits?
• Genetic analysis of neurodegenerative diseases