1998/03/26 by Maksim Skorobogatiy, Hong Guo, Martin J. Zuckermann
Physics and Astronomy · Biochemistry, Genetics and Molecular Biology · #cond-mat.soft #q-bio
published as Maxim Skorobogatiy, Hong Guo, Martin Zuckerman, Macromolecules, vol. 30(11), pp. 3403-3410, (1997) · 15 pages, 4 figures
arxiv created 1998/03/26 · arxiv updated 2009/11/30
We have considered the problem of protein design based on a model where the contact energy between amino acid residues is fitted phenomenologically using the Miyazawa--Jernigan matrix. Due to the simple form of the contact energy function, an analytical prescription is found which allows us to design energetically stable sequences for fixed amino acid residues compositions and target structures. The theoretically obtained sequences are compared with real proteins and good correspondence is obtained. Finally we discuss the effect of discrepancies in the procedure used to fit the contact energy on our theoretical predictions.