1997/10/02 by Ugo Bastolla, Helge Frauenkron, Erwin Gerstner +2
Physics and Astronomy · Biochemistry, Genetics and Molecular Biology · #cond-mat.stat-mech #q-bio
published as Proteins: Structure, Function, and Genetics Vol. 32 (1998) 52--66 · 13 pages, RevTeX, needs epsfig.sty and multicolum.sty
arxiv created 1997/10/02 · arxiv updated 2009/11/30
We demonstrate that the recently proposed pruned-enriched Rosenbluth method PERM (P. Grassberger, Phys. Rev. E, in press (1997)) leads to extremely efficient algorithms for the folding of simple model proteins. We test it on several models for lattice heteropolymers, and compare to published Monte Carlo studies of the properties of particular sequences. In all cases our method is faster than the previous ones, and in several cases we find new minimal energy states. In addition to producing more reliable candidates for ground states, our method gives detailed information about the thermal spectrum and, thus, allows to analyze static aspects of the folding behavior of arbitrary sequences.