2005/08/23 by Cristian Staii, Alan T. Johnson, Michelle Chen +2
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Advanced Chemical Sensor Technologies #Advanced biosensing and bioanalysis techniques #Nanopore and Nanochannel Transport Studies #cond-mat.mtrl-sci #cond-mat.str-el
paper · pdf · doi:10.1021/nl051261f
9 pages, 5 figures, Nano Letters web release: 23-Aug-2005
openalex publication_date 2005/08/23 · arxiv created 2005/09/02 · arxiv updated 2009/12/01 · openalex created_date 2017/10/20 · openalex updated_date 2026/08/01
We demonstrate a new, versatile class of nanoscale chemical sensors based on single-stranded DNA (ss-DNA) as the chemical recognition site and single-walled carbon nanotube field effect transistors (swCN-FETs) as the electronic read-out component. swCN-FETs with a nanoscale coating of ss-DNA respond to gas odors that do not cause a detectable conductivity change in bare devices. Responses of ss-DNA/swCN-FETs differ in sign and magnitude for different gases and can be tuned by choosing the base sequence of the ss-DNA. ss-DNA/swCN-FET sensors detect a variety of odors, with rapid response and recovery times on the scale of seconds. The sensor surface is self-regenerating: samples maintain a constant response with no need for sensor refreshing through at least 50 gas exposure cycles. This remarkable set of attributes makes sensors based on ss-DNA decorated nanotubes very promising for "electronic nose" and "electronic tongue" applications ranging from homeland security to disease diagnosis.