Single Stranded DNA Translocation Through A Nanopore: A Master Equation Approach

2003/07/17 by O. Flomenbom, J. Klafter
Physics and Astronomy · Biochemistry, Genetics and Molecular Biology · #cond-mat.stat-mech #q-bio.SC

paper · pdf · doi:10.1103/physreve.68.041910

published as Phys. Rev. E 68, 041910 (2003) · 7 pages submitted to PRE

arxiv created 2003/07/17 · arxiv updated 2009/11/30

Abstract

We study voltage driven translocation of a single stranded (ss) DNA through a membrane channel. Our model, based on a master equation (ME) approach, investigates the probability density function (pdf) of the translocation times, and shows that it can be either double or mono-peaked, depending on the system parameters. We show that the most probable translocation time is proportional to the polymer length, and inversely proportional to the first or second power of the voltage, depending on the initial conditions. The model recovers experimental observations on hetro-polymers when using their properties inside the pore, such as stiffness and polymer-pore interaction.

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