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First-principles approach to electrorotation assay

2001/07/31 by J. P. Huang, J P Huang, K. W. Yu +1 · 1 citation
Chemistry · Engineering · Physics and Astronomy · #Electrochemical Analysis and Applications #Electrostatics and Colloid Interactions #Microfluidic and Bio-sensing Technologies #cond-mat.soft #physics.bio-ph

paper · pdf · doi:10.1088/0953-8984/14/6/308

published as J. Phys.: Condens. Matter 14, 1213 (2002) · 17 pages, 4 eps figures; minor revisions, accepted for publications by J. Phys.: Condens. Matter

arxiv created 2002/01/19 · openalex publication_date 2002/01/31 · arxiv updated 2009/11/30 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/30

Abstract

We have presented a theoretical study of electrorotation assay based on the spectral representation theory. We consider unshelled and shelled spheroidal particles as an extension to spherical ones. From the theoretical analysis, we find that the coating can change the characteristic frequency at which the maximum rotational angular velocity occurs. The shift in the characteristic frequency is attributed to a change in the dielectric properties of the bead-coating complex with respect to those of the uncoated particles. By adjusting the dielectric properties and the thickness of the coating, it is possible to obtain good agreement between our theoretical predictions and the assay data.

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