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A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties

2001/04/23 by M-T. Kechadi, R. G. Reilly, K. A. Dawson +2
Physics and Astronomy · Biochemistry, Genetics and Molecular Biology · #cond-mat.soft #cond-mat.dis-nn #q-bio

paper · pdf

published as Il Nuovo Cimento. Vol. 20D, No 12bis, pp. 2383-2391 (1998) · 11 pages incl. 6 PS figures. Paper presented at the International Conference on Morphology and Kinetics of Phase Separating Complex Fluids, Messina, Italy, June 1997

arxiv created 2001/04/23 · arxiv updated 2009/11/30

Abstract

In this paper we present a method to study the folding structure of a simple model consisting of two kinds of monomers, hydrophobic and hydrophilic. This method has three main steps: an efficient simulation method to bring an open sequence of homopolymer to a folded state, the application of a painting method called (regular hull) to the folded globule and the refolding process of the obtained copolymer sequence. This study allows us to suggest a theoretical function of disorder distribution for copolymer sequences that give rise to a compacted and well micro-phase separated globule.

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