2000/10/31 by Somendra M. Bhattacharjee
Physics and Astronomy · Biochemistry, Genetics and Molecular Biology · #cond-mat.stat-mech #cond-mat.soft #physics.bio-ph #q-bio
published as Indian J. Phys. A 85A, 69 (2002) · 5 pages, latex/revtex, 1 eps figures. Corrected typos, reference list updated. Proceedings of CMDAYS2K, held at Guru Ghasidas University, Bilaspur, India, Aug 29-31, 2K
arxiv created 2000/11/13 · arxiv updated 2009/11/30
Based on the result of an unzipping phase transition by a force in a model of DNA, we hypothesize that the DnaA-type proteins act as a pulling agent with a force slightly less than the critical force for unzipping. The dynamic (space-time) correlation of unzipping then drives the subsequent events of replication. In such a correlation driven scenario, there is no need of a replisome as a structural unit and this elusive replisome may not exist at all.