2024/11/29 by Pattriya Jirawattanadon, Sumanas Bunyaratavej, Charussri Leeyaphan +8 · 1 voice
Medicine · #Antifungal resistance and susceptibility #Fungal Infections and Studies #Nail Diseases and Treatments
paper · doi:10.3201/eid3012.240467
openalex publication_date 2024/11/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
We analyzed clinical manifestations, antifungal susceptibility, and treatment outcomes of cutaneous sporotrichosis in Thailand during 2018-2022. The study included 49 patients whose mean age was 58.7 (SD 16.9) years; 65.3% were female and 34.7% male. A history of cat exposure was reported in 32 (65.3%) patients who had a significantly higher prevalence of upper extremity lesions than did those without cat contact (90.6% vs. 41.7%; adjusted odds ratio 18.9 [95% CI 3.2-92.9]). Among patients >60 years of age, lesions were more likely to be nonpustular than for patients <60 years of age (82.1% vs. 52.4%; p = 0.033). All 9 isolates tested for antifungal drug susceptibility exhibited an itraconazole MIC of <1 μg/mL. Oral itraconazole monotherapy was effective; the median time-to-cure was 180 days (interquartile range 141-240 days). Physicians should heighten their awareness of potential sporotrichosis causes, particularly when a history of animal contact exists.