Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis

2024/12/30 by Mark P. Ward, M.P. Ward, E.M. Ibrahim +11 · 1 voice · 1 citation
Medicine · #Blood Coagulation and Thrombosis Mechanisms #Cerebral Venous Sinus Thrombosis #Venous Thromboembolism Diagnosis and Management

paper · pdf · doi:10.1016/j.thromres.2024.109251

openalex publication_date 2024/12/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Cited by

• Mechanisms of anticancer treatment-induced arterial and venous thrombosis

Discussions

• Is #cancer associated #thrombosis caused predominantly by the tumour or treatment. #chemotherapy has unique effects on the activated protein C pathway which may be important in VTE occuring during che [bsky, 6 points, 0 comments]