2019/01/25 by Sylvain Cussat-Blanc, Sylvain Cussat‐Blanc, Kyle Harrington +1
Biochemistry, Genetics and Molecular Biology · Computer Science · #Evolution and Genetic Dynamics #Evolutionary Algorithms and Applications #Gene Regulatory Network Analysis
paper · pdf · doi:10.1162/artl_a_00267
openalex publication_date 2019/01/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26
In nature, gene regulatory networks are a key mediator between the information stored in the DNA of living organisms (their genotype) and the structural and behavioral expression this finds in their bodies, surviving in the world (their phenotype). They integrate environmental signals, steer development, buffer stochasticity, and allow evolution to proceed. In engineering, modeling and implementations of artificial gene regulatory networks have been an expanding field of research and development over the past few decades. This review discusses the concept of gene regulation, describes the current state of the art in gene regulatory networks, including modeling and simulation, and reviews their use in artificial evolutionary settings. We provide evidence for the benefits of this concept in natural and the engineering domains.