2022/01/01 by Rosália Morais Tôrres, Rosália Morais Torres, Dalmo Correia +17 · 36 citations
Medicine · #Cardiology #Cardiomyopathy #Cardiomyopathy and Myosin Studies #Chagas disease #Disease #Epidemiology #Heart disease #Heart failure #Heart transplantation #Intensive care medicine #Internal medicine #Medicine #Pathology #Public health #Trypanosoma species research and implications #Viral Infections and Immunology Research
paper · pdf · doi:10.1590/0074-02760210172
published in Memórias do Instituto Oswaldo Cruz 117, e210172 (Instituto Oswaldo Cruz, Ministério da Saúde)
openalex publication_date 2022/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.