1984/12/01 by Zilton A. Andrade, E. Van Marck · 1 citation
Immunology and Microbiology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Drug-Induced Hepatotoxicity and Protection #Liver Diseases and Immunity #Parasites and Host Interactions
paper · pdf · doi:10.1590/s0074-02761984000400017
openalex publication_date 1984/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/19
In this review paper schistosomal glomerulopathy is defined as an immune-complex disease. The disease appears in 12-15 per cent of the individuals with hepatosplenic schistosomiasis. Portal hypertension with collateral circulation helps the by pass of the hepatic clearance process and the parasite antigens can bind to antibodies in the circulation and be trapped in the renal glomerulus. Chronic membranous-proliferative glomerulonephritis is the most common lesion present and the nephrotic syndrome is the usual form of clinical presentation. The disease can be experimentally produced, and schistosomal antigens and antibodies, as well as complement, can be demonstrated in the glomerular lesions. Specific treatment of schistosomiasis does not seem to alter the clinical course of schistosomal nephropathy.