1992/05/01 by Donald, M. Walsh, Maoliosa Donald, Henry D. Royal · 1 citation
Medicine · Veterinary · #Pediatric Urology and Nephrology Studies #Veterinary Equine Medical Research #Veterinary Medicine and Surgery
paper · doi:10.2460/ajvr.1992.53.05.776
openalex publication_date 1992/05/01 · openalex created_date 2022/08/07 · openalex updated_date 2026/07/30
Summary Glomerular filtration rate ( gfr ) was measured in 12 clinically normal horses, using the standard inulin clearance method, and values were compared with values for 2 methods, using a single rapid iv injection of 99m Tc-la-beled diethylenetriaminepentaacetic acid ( 99m Tc- dtpa ). The first 99m Tc- dtpa method used a 2-compartment model to calculate gfr blood clearance of the tracer. The second method used sequential digital gamma camera images of the kidneys to determine fractional accumulation of the total dose of the tracer in the kidneys (percentage of injected dose, gamma camera) from 0 to 10 minutes after radionuclide administration. Linear correlation among the 3 methods was determined. Mean (± SD) gfr , using the inulin clearance method, was 154.67 ± 42.28 ml/min/100 kg of body weight. Mean gfr , using the 2-compartment blood clearance curve, was 146.92 ± 27.49 ml/min/100 kg. Mean gfr , using percentage of injected dose (gamma camera method) was 154.7 ± 22.00 ml/min/100 kg. The percentage of injected dose (gamma camera method) did not correlate significantly to the inulin clearance results. However, a significant ( r = 0.666, P < 0.018) correlation was observed between the inulin method and the 99m Tc- dtpa blood clearance method. Significant ( P < 0.0001) difference also was observed in the split function of the equine kidneys, with gfr of the right kidney contributing 60.1 ± 9.12% of the total function, as determined by 99m Tc- dtpa gamma camera imaging. Because the 99m Tc- dtpa blood clearance method does not require urine collection, it may be a more practical procedure to measure gfr in the horse.