2025/03/02 by Elise Rees, Isabella Sodi, Kane Foster +26 · 1 voice
Medicine · #Acute Myeloid Leukemia Research #Chemokine receptors and signaling #Multiple Myeloma Research and Treatments
paper · pdf · doi:10.1101/2025.02.26.640356
openalex publication_date 2025/03/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
Abstract Natural killer (NK) cells play a key role in the innate immune response against tumour progression. While the immune microenvironment in multiple myeloma (MM) becomes increasingly dysfunctional during disease evolution, little is known about changes in the NK cell compartment. Using primary samples from clinical trial patients, we performed detailed phenotypic analyses of bone marrow mononuclear cells from MGUS, SMM, and newly diagnosed MM patients. We found that disease progression is associated with an increase in CD56 bright NK cells with a dynamic positive association between this NK cell subset and local tumour burden. We generated a large single-cell RNA sequencing dataset of >100,000 NK cells from healthy donor individuals and plasma cell disorder patients and identify a bone marrow specific CD56 bright -like NK cell population (BM-NK) that is enriched in the marrow of MM patients. These findings highlight the evolution of the NK-cell compartment in MM and suggest a role for BM-resident CD56 bright NK cells with impaired cytotoxicity in promoting immune evasion.