Tumour hypoxia in driving genomic instability and tumour evolution

2025/01/28 by Alexandru Suvac, Jack Ashton, Robert G. Bristow · 1 voice
Biochemistry, Genetics and Molecular Biology · #Cancer, Hypoxia, and Metabolism #Microtubule and mitosis dynamics #Mitochondrial Function and Pathology

paper · doi:10.1038/s41568-024-00781-9

openalex publication_date 2025/01/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
• A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
• Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
• Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Discussions

• How does tumour hypoxia drive poor outcomes in men with #prostatecancer? Prof. Robert Bristow and team @official-uom.bsky.social, funded by Movember FASTMAN Centre of Excellence, review how hypoxia d [bsky, 6 points, 0 comments]