Making sense of fat in cancer

2025/03/13 by Estela Jacinto · 1 voice
Biochemistry, Genetics and Molecular Biology · #Cancer, Hypoxia, and Metabolism #Cancer, Lipids, and Metabolism #Lipid metabolism and biosynthesis

paper · doi:10.1126/science.adw1956

openalex publication_date 2025/03/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

A lipid chaperone enables sensing of an essential fatty acid to drive tumor growth.

Citations

• Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Discussions

• Triple-negative breast cancer cells crave omega-6 linoleic acid. Why? FABP5 helps shuttle this fat to mTORC1, activating cell growth even without amino acids. Blocking this fat–protein axis might offe [bsky, 6 points, 0 comments]

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