Proportions of US Blood Donors With Serological Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections Who Reported Survey-Based Diagnosed Infections During July 2020–December 2022

2025/04/10 by Akintunde Akinseye, David J. Wright, Eduard Grebe +8 · 1 voice
Medicine · #SARS-CoV-2 and COVID-19 Research #COVID-19 Clinical Research Studies #COVID-19 Impact on Reproduction

paper · pdf · doi:10.1093/ofid/ofaf210

Abstract

The proportion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections diagnosed by coronavirus disease 2019 (COVID-19) tests, including home antigen tests, is unknown. We detected infections among blood donors in the United States (US) by testing for nucleocapsid antibody (anti-N) seroconversion and administered a questionnaire to determine the proportion of those infections that were associated with a self-reported positive COVID-19 test. Among US blood donors with serologic evidence of SARS-CoV-2 infection who completed a survey, 47.7% reported an associated self-reported positive COVID-19 test. This proportion changed from July-December 2020 (44.9%) to July-December 2022 (54.8%). This study suggests many SARS-CoV-2 infections in adults are not diagnosed with a test.

Discussions

• Proportions of U.S. Blood Donors with Serological Evidence of SARS-CoV-2 Infections Who Reported Survey-Based Diagnosed Infections During July 2020-December 2022 ✅ Just Accepted #IDSky [bsky, 6 points, 0 comments]

Related

• Serologic Testing of US Blood Donations to Identify Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Reactive Antibodies: December 2019–January 2020
• Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the District of Columbia, United States—October 25, 2020–February 26, 2022
• How do we decide how representative our donors are for public health surveillance?
• Prevalence of Asymptomatic SARS-CoV-2 Infection
• Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples