Deciphering disordered regions controlling mRNA decay in high-throughput

2025/04/23 by Joseph H. Lobel, Nicholas T. Ingolia · 1 voice · 9 citations
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #RNA and protein synthesis mechanisms #RNA modifications and cancer

paper · doi:10.1038/s41586-025-08919-x

openalex publication_date 2025/04/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Citations

• Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
• A large-scale binding and functional map of human RNA-binding proteins
• Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences
• PANTHER: Making genome‐scale phylogenetics accessible to all
• ColabFold: making protein folding accessible to all

Cited by

• Into the Unknown: From Structure to Disorder in Protein Function Prediction

Discussions

• From @nickingolia.bsky.social at @ucberkeleyofficial.bsky.social 🧪🧬🖥️ Disordered protein regions hold powerful sway over gene expression, as this new large-scale study reveals how they regulate mRN [bsky, 6 points, 0 comments]