Gene Ontology: tool for the unification of biology

2000/05/01 by Michael Ashburner, Catherine A. Ball, Judith A. Blake +20 · 462 citations
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Biomedical Text Mining and Ontologies #Microbial Metabolic Engineering and Bioproduction

paper · doi:10.1038/75556

openalex publication_date 2000/05/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Citations

• The Gene Ontology resource: enriching a GOld mine

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• Genome sequence and comparative analysis of reindeer (Rangifer tarandus) in northern Eurasia
• Towards Autonomous Mechanistic Reasoning in Virtual Cells
• Probabilistic annotation of protein sequences based on functional classifications
• Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori
• Resultados del tratamiento de niños diagnosticados de linfomas no Hodgkin y leucemias linfoblásticas agudas de células B tratados con protocolos BFM. Informe del GOPM
• Floral gene resources from basal angiosperms for comparative genomics research
• Ancestral polyploidy in seed plants and angiosperms
• Differences between fast and slow muscles in scallops revealed through proteomics and transcriptomics
• Comprehensive Overview of Bottom-up Proteomics using Mass Spectrometry
• The fire ant social chromosome supergene variant Sb shows low diversity but high divergence from SB
• Forensics and Privacy-Enhancing Technologies - Logging and Collecting Evidence in Flocks.
• Modeling multi-scale data via a network of networks
• Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex
• Discovering statistically significant biclusters in gene expression data
• Nonspecific expression of fertilization genes in the crown‐of‐thorns Acanthaster cf. solaris: Unexpected evidence of hermaphroditism in a coral reef predator
• Exploring tissue architecture using spatial transcriptomics
• DataParasite Enables Scalable and Repurposable Online Data Curation
• MethConvTransformer: A Deep Learning Framework for Cross-Tissue Alzheimer's Disease Detection
• Scaffolding the Mitochondrial Disease Ontology from extant knowledge sources
• Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
• Possible connection between imidacloprid-induced changes in rice gene transcription profiles and susceptibility to the brown plant hopper Nilaparvata lugens Stål (Hemiptera: Delphacidae)
• Evolutionary and Biomedical Insights from the Rhesus Macaque Genome
• The genomic impact of 100 million years of social evolution in seven ant species
• DeepBrain: Functional Representation of Neural In-Situ Hybridization Images for Gene Ontology Classification Using Deep Convolutional Autoencoders
• Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
• Genome of the human hookworm Necator americanus
• Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South Asia
• Calling International Rescue: knowledge lost in literature and data landslide!
• Understanding the Systems Biology of Pathogen Virulence Using Semantic Methodologies
• Investigation of human leukocyte antigen alleles as risk factors for cryptococcal disease in Ugandan individuals with HIV
• AligNet: Alignment of Protein-Protein Interaction Networks
• Validating module network learning algorithms using simulated data
• Estimation of Simultaneous Signals Using Absolute Inner Product with Applications to Integrative Genomics
• Genetic properties underlying transcriptional variability across different perturbations
• Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis
• A Top-down Supervised Learning Approach to Hierarchical Multi-label Classification in Networks
• Hybrid natural language processing for high-performance patent and literature mining in IBM Watson for Drug Discovery
• ECHO-PPI: Evidence-Bundled Overlapping Protein Module Detection with Hierarchical Assignment Confidence for Network Biology
• Efficient and scalable geometric hashing method for searching protein 3D structures
• NCBO Ontology Recommender 2.0: an enhanced approach for biomedical ontology recommendation
• Using Entropy Estimates for DAG-Based Ontologies
• Accelerating Science: A Computing Research Agenda
• Neuro-symbolic representation learning on biological knowledge graphs
• The telomere-to-telomere gap-free reference genome and taxonomic reassessment of Siniperca roulei
• Bayesian joint modeling of multiple gene networks and diverse genomic data to identify target genes of a transcription factor
• Comparing Classical Pathways and Modern Networks: Towards the Development of an Edge Ontology
• Aber-OWL: a framework for ontology-based data access in biology
• Translocatome: a novel resource for the analysis of protein translocation between cellular organelles
• DeepSpot: Leveraging Spatial Context for Enhanced Spatial Transcriptomics Prediction from H&E Images
• Phylogenomics of 10,575 genomes reveals evolutionary proximity between domains Bacteria and Archaea
• A functional update of the Escherichia coliK-12 genome
• Statistical Properties and Robustness of Biological Controller-Target Networks
• Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities
• eXamine: a Cytoscape app for exploring annotated modules in networks
• Combined Hypothesis Testing on Graphs with Applications to Gene Set Enrichment Analysis
• Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 downregulates key regulatory systems in the chondrocyte mechanome
• Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer
• The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila
• THBKG: A Temporal Biomedical Knowledge Graph for Decision-Aligned Clinical Advancement Prediction
• Oxidative stress gene signature associated with vitiligo: A multi-algorithm machine learning and Mendelian randomization validation
• An automated method for finding molecular complexes in large protein interaction networks
• A neuronal blood marker is associated with mortality in old age
• The human liver‐specific proteome defined by transcriptomics and antibody‐based profiling
• Integrative analysis of 111 reference human epigenomes
• Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
• Haplotype-resolved genome assembly and genome-wide association study identifies the candidate gene closely related to sugar content and tuber yield in Solanum tuberosum
• Using R and Bioconductor for proteomics data analysis
• Multi-way blockmodels for analyzing coordinated high-dimensional responses
• Genome characteristics reveal the impact of lichenization on lichen-forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota)
• Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
• Towards Semantic Big Graph Analytics for Cross-Domain Knowledge Discovery
• The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans
• The genomic landscape of Neanderthal ancestry in present-day humans
• Neanderthal Introgression at Chromosome 3p21.31 Was Under Positive Natural Selection in East Asians