Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

2020/08/17 by Hoon Kim, Nam-Phuong Nguyen, Nam Nguyen +20 · 12 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer Genomics and Diagnostics #Genetic factors in colorectal cancer #Molecular Biology Techniques and Applications

paper · doi:10.1038/s41588-020-0678-2

openalex publication_date 2020/08/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Citations

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
• Pan-cancer analysis of whole genomes

Cited by

• Targeting extrachromosomal DNA in human cancers
• EcDNA-borne structural variants drive oncogenic fusion transcript amplification
• Mitotic chromatin compaction tethers extrachromosomal DNA to chromosomes and prevents their mis-segregation into micronuclei
• Cis and trans regulatory mechanisms of extrachromosomal DNA segregation
• Targeting Extrachromosomal DNA in Cancer: A New Frontier in Precision Oncology
• Emergence of population-level feedback control by transposon-plasmid coevolution
• eccDNABase: A Comprehensive and High-Quality Database for Extrachromosomal Circular DNA
• Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma
• The newfound relationship between extrachromosomal DNAs and excised signal circles
• Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
• A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome
• ECLIPSE: A Composable Pipeline for Predicting ecDNA Formation, Evolution, and Therapeutic Vulnerabilities in Cancer