The L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation, and is embryonic lethal in homozygous CRISPR gene-edited mice

2025/04/11 by Rachel L. Sadler, Rachel Sadler, Angela Greenman +4 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #CRISPR and Genetic Engineering #Cardiomyopathy and Myosin Studies #Viral Infectious Diseases and Gene Expression in Insects

paper · doi:10.1016/j.yjmcc.2025.04.007

openalex publication_date 2025/04/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Cited by

• Myosin‐binding protein C slows cardiac myofibril relaxation kinetics

Discussions

• 🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic [bsky, 6 points, 0 comments]