MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences

2008/06/19 by Marty C. Brandon, Eduardo Ruiz-Pesini, Eduardo Ruiz‐Pesini +8
Biochemistry, Genetics and Molecular Biology · #Metabolism and Genetic Disorders #Metabolomics and Mass Spectrometry Studies #Mitochondrial Function and Pathology

paper · doi:10.1002/humu.20801

openalex publication_date 2008/06/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

We have developed a computer system, MITOMASTER, to make analysis of human mitochondrial DNA (mtDNA) sequences efficient, accurate, and easily available. From imported sequences, the system identifies nucleotide variants, determines the haplogroup, rules out possible pseudogene contamination, identifies novel DNA sequence variants, and evaluates the potential biological significance of each variant. This system should be beneficial for mtDNA analyses of biomedical physicians and investigators, population biologists and forensic scientists. MITOMASTER can be accessed at http://mammag.web.uci.edu/twiki/bin/view/Mitomaster.

Citations

• The structure of human mitochondrial DNA variation
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

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