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Mapping the electrostatic profiles of cellular membranes

2021/02/01 by Sharon Eisenberg, Ehud Haimov, Glenn F. W. Walpole +3

paper · doi:10.1091/mbc.e19-08-0436

Abstract

We used genetically encoded fluorescent probes to determine the surface charges of organellar membranes. The inner leaflet of the plasma membrane was found to be the most negative, with a surface potential of approximately –35 mV, followed by the Golgi complex > lysosomes > mitochondria ≈ peroxisomes > the endoplasmic reticulum, in decreasing order.

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