2017/08/02 by Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui +1
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Nerve injury and regeneration #Neurogenesis and neuroplasticity mechanisms #Pluripotent Stem Cells Research
paper · pdf · doi:10.1002/dvdy.24558
openalex publication_date 2017/08/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75-84, 2018. © 2017 Wiley Periodicals, Inc.