2026/07/20 by Amy M. Berkman, Shalini Bhatia, Sedigheh Mirzaei Salehabadi +20
Medicine · #Acute Lymphoblastic Leukemia research #Childhood Cancer Survivors' Quality of Life #Glioma Diagnosis and Treatment
paper · doi:10.1158/1055-9965.epi-26-0609
openalex publication_date 2026/07/20 · openalex created_date 2026/07/21 · openalex updated_date 2026/07/21
BACKGROUND: Survivors of childhood cancer face elevated risks for treatment‑related late effects, including subsequent malignant neoplasms (SMNs). In the general population, accelerated aging is associated with increased malignancy risk, however this has not been evaluated in survivors. METHODS: Survivors enrolled in the Childhood Cancer Survivor Study with measures of physiologic frailty, Cumulative Illness Burden for Geriatrics (CIRS-G), or Deficit Accumulation Index (DAI) data were included. Associations between these measures of accelerated aging with SMNs, benign meningiomas, and non-melanoma skin cancers (NMSC) were estimated with piecewise exponential models, adjusted for sociodemographic, treatment, and modifiable factors. RESULTS: Physiologic frailty and CIRS‑G were not associated with risk of SMNs, meningiomas, or NMSCs. Higher DAI was only associated with increased risk of benign meningioma, but not SMNs or NMSCs. CONCLUSIONS: Accelerated aging measures were not consistently associated with SMN risk in survivors of childhood cancer. IMPACT: Our results confirm that established risk factors, especially treatment exposures, remain critical in the development of SMN in survivors, reinforcing the importance of risk‑adapted therapies and long‑term surveillance in survivorship care.