The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations

2022/08/30 by Ryan P. Joyce, Ryan Joyce, Vivian W. Hu +1 · 1 citation
Computer Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Computational Drug Discovery Methods #Pharmacogenetics and Drug Metabolism #SARS-CoV-2 and COVID-19 Research

paper · pdf · doi:10.1007/s00044-022-02951-6

openalex publication_date 2022/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Citations

• A new coronavirus associated with human respiratory disease in China
• Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
• Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines

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• CYP3A4 drug metabolism considerations in pediatric pharmacotherapy