2018/08/03 by Shirley Man, Gonzalo Sanchez Duffhues, Gonzalo Sánchez‐Duffhues +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Congenital Diaphragmatic Hernia Studies #Congenital heart defects research #Mesenchymal stem cell research
paper · pdf · doi:10.1007/s10456-018-9639-0
openalex publication_date 2018/08/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Endothelial cells (ECs) have been found to be capable of acquiring a mesenchymal phenotype through a process known as endothelial-to-mesenchymal transition (EndMT). First seen in the developing embryo, EndMT can be triggered postnatally under certain pathological conditions. During this process, ECs dedifferentiate into mesenchymal stem-like cells (MSCs) and subsequently give rise to cell types belonging to the mesoderm lineage. As EndMT contributes to a multitude of diseases, pharmacological modulation of the signaling pathways underlying EndMT may prove to be effective as a therapeutic treatment. Additionally, EndMT in ECs could also be exploited to acquire multipotent MSCs, which can be readily re-differentiated into various distinct cell types. In this review, we will consider current models of EndMT, how manipulation of this process might improve treatment of clinically important pathologies and how it could be harnessed to advance regenerative medicine and tissue engineering.