2025/11/01 by Raphaël M. J. Fischer, Nicolas Muñoz, Olivia Ong +3
paper · doi:10.1111/ctr.70389
ABSTRACT Background Normothermic regional perfusion (NRP) is rapidly gaining adoption for donation after cardiac death (DCD) organ recovery in the United States. However, little is known about trends in NRP procured grafts for simultaneous pancreas–kidney transplantation (SPK). Design SPK recipients between January 2021 and June 2025 were identified using the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) national data. Patients DCD‐SPK donors and recipients were included and grouped by recovery method. Measurements Donor and recipient demographic data were described. Primary outcomes were pancreas and kidney graft survival at 1 year, evaluated with Kaplan–Meier survival curves. Kidney outcomes included delayed graft function and creatinine levels. Results A total of 137 DCD SPKs were included, with NRP and super‐rapid recovery (SRR) performed in 33 (24%) and 104 (76%) of donors, respectively. Donors in the NRP group were older (28 [22–34] vs. 22 [18–29], p p p p p = 0.054), with similar 1‐year values. One‐year pancreas and kidney graft survival following NRP were 91% and 100%, respectively. Conclusions Since the introduction of NRP, 24% of the DCD‐SPK grafts were procured with NRP. Comparable 1‐year kidney and pancreas graft survival between SRR and NRP with lower rates of kidney dysfunction following NRP.