SRD5A1 Genotype Frequency Differences in Women with Mild versus Severe Premenstrual Symptoms

2012/01/24 by Marlene Adams, Susan McCrone
Medicine · #Biochemical effects in animals #Herbal Medicine Research Studies #Menstrual Health and Disorders

paper · doi:10.3109/01612840.2011.625514

openalex publication_date 2012/01/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

The aims of this small pilot study were to explore the association between premenstrual symptom severity and two genes from the gamma-aminobutyric acid (GABA) pathway: steroid-5-alpha-reductase, alpha polypeptide 1 (SRD5A1) and gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4). Saliva samples were obtained from a convenience sample of 19 Caucasian females ages 18-25 years, ten cases and nine controls. Deoxyribonucleic acid (DNA) was isolated, and genotyping performed on ten single nucleotide polymorphisms (SNPs). Ten percent of cases and 44% of controls had the cytosine/cytosine (C/C) genotype for the SRD5A1 SNP, rs501999 indicating that this genotype may protect women against severe premenstrual symptoms. Replication of this study using an adequately powered sample size is warranted.

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