The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia

2016/09/09 by Gilles M. Leclerc, Shuhua Zheng, Guy J. Leclerc +4
Biochemistry, Genetics and Molecular Biology · #Endoplasmic Reticulum Stress and Disease #Protein Degradation and Inhibitors #Ubiquitin and proteasome pathways

paper · doi:10.1016/j.leukres.2016.09.007

openalex publication_date 2016/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
• Cancer statistics, 2012