2008/08/21 by Fayang Qiu, Fayang G. Qiu · 1 citation
Biochemistry, Genetics and Molecular Biology · Computer Science · Engineering · #Chemical Synthesis and Analysis #Computational Drug Discovery Methods #Innovative Microfluidic and Catalytic Techniques Innovation
paper · doi:10.1139/v08-120
openalex publication_date 2008/08/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
A standard for gauging the efficiency of synthetic strategies has been proposed. Synthetic efficiency is correlated to the molecular-complexity index, which is the cumulative total number of chiral centers, independent functional groups, and rings contained in a molecule. The number of reaction steps for an efficient synthetic design must be smaller than that of molecular-complexity index. This standard will motivate organic chemists to work harder on the synthetic design prior to execution.Key words: strategic efficiency, total synthesis, synthetic design, complexity index.